Endocrine Abstracts

Introduction: Hypothyroidism is a chronic pathology, which can have several etiologies and which requires long-term treatment. The modification of meal times during the month of Ramadan which can modify the absorption of L-thyroxine, knowing that it interferes with the taking of meals. Purpose of the study: Assess the impact of L-thyroxine intake schedule on the therapeutic balance during Ramadan in patients with hypothyroidism.Mat...

Background: Hashimoto’s thyroiditis is a chronic autoimmune thyroiditis. It is the most common cause of primary hypothyroidism in adolescent period, via autoimmune thyroid tissue destruction and affecting 2% of the population. In this study we want to investigate the role of the cytokines such as IL-2, IL-12, TNF-α and IFN-γ in the pathogenesis of the disease and the changes of cytokine levels with the L-thyroxine treatment....

Introduction: The prevalence of impaired fasting glucose (IFG) in the elderly approaches 50% in some community-dwelling cohorts. We examined whether IFG is associated with a higher burden of disease, cardiovascular risk factors and circulating low-grade inflammation than in normoglycemic elderly people.Methods/Design: Cross-sectional data of 929 participants of the Sydney Memory and Aging Study (MAS) were examined. MAS is a population-derived cohort of c...

Introduction: Pituitary insufficiency of the adult is a rare pathology (~30–40/1 000 000 per year). Among the acquired causes, Sheehan syndrome (SS) is often characterized by an insidious evolution, which allows it to pass unnoticed for a long time.Case report: R Maria, 58 years-old, known with SS for 10 years, was hospitalized in the ER with severe asthenia, obnubilation, symptomatic arterial hypotension. Laboratory studies revealed severe hyponatr...

Introduction: Androgen deficiency (AD) is associated with endothelial and erectile dysfunction, lower urinary tract symptoms (LUTS) and reduced quality of life (QoL) in obesity. We aimed to compare effects of weight loss induced by lifestyle modification on endothelial and erectile function, LUTS and QoL in obese men with and without AD.Methods: abdominally obese Asian (body mass index≥30 kg/m2, waist circumference [WC] ≧ 90 cm) m...

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

Aim: We report a child with reactive pituitary enlargement and microadenoma due to Hashimoto thyroiditis.We want to emphasize the importance of good endocrine evaluation in pediatric cases of pituitary adenomasCase report: A 7 year 7 month old boy presented with mild symptoms of hypothyroidism. There was no feature in his past medical story.He had normal cognitive and neurological development. At physical examination his weight was 24 kg (0.06 SDS) and h...

Obstructive sleep apnoea (OSA)is associated with increased cardiovascular morbidity and mortality and is an independent risk factor for the development of hypertension. A recent study demonstrated elevated urinary catecholamine excretion in hypertensive males with OSA. However, we have recently observed the phenomenum whereby OSA can rarely induce catecholamine production of sufficient severity to mimic the clinical and biochemical presentation of phaeochromocytoma.<p clas...

Isoflavones are a subgroup of phytoestrogens and have a chemical structure similar to oestrogen, leading to concerns regarding possible adverse effects of isoflavones in men. Testosterone levels in men with type 2 diabetes mellitus (T2DM) are lower.Materials and methods: A randomised double-blind, parallel study was undertaken with 200 men with T2DM, of median age of 50 years (25th/75th centiles; 50, 55) years with a total testosterone level ≤12 nm...

Background: The need for improved glycaemic control in children with type 1 diabetes in Scotland is well recognised; DIABAUD 3 identified that only 9.7% achieved the national HbA1c target.Aim: To evaluate whether a change from three times daily injection regimen to a basal bolus regimen with carbohydrate counting at diagnosis will result in an improvement in immediate and longer term glycaemic control.Method: We included children &...